Expected heterozygosity in lositan

Question

[emma.berdan]

Hello,

Does anyone know how the expected heterozygosity in lostian is calculated? I tried to find the equation but came up empty handed. The He reported in the program is on a scale from 0-1 so it is not simply a 2pq situation.

Answer 1

[tiagoantao]

In Lositan the Heterozygosity is h_b rather than h_t - i.e. it is the probability of choosing two alleles at random that are different, one from each deme, rather than the prob of picking two alleles at random that are different irrespective of deme. With two demes it can reach 1 when FST is 1. So the reason why it is so high is that you are probably looking at very inbred populations.