small non-coding RNA
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10.2 years ago
biofalconch ★ 1.3k

Hello, I'm working with smRNA but found several databases or simply no bases at all for some of them. Can you recommend databases for the next types of smRNA?

  • piRNA
  • snoRNA
  • snRNA

Thanks in advance!

smRNA • 2.1k views
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10.2 years ago

Ensembl annotates snoRNAs and snRNAs, so you can use any of their annotations (or even biomart) for those. For piRNAs, I know there's piRNAbank.

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Any thoughts on this database for snoRNA?

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Given that it's human only, seems to be using the hg18 build, and appears to have been last updated a few years ago...

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And is there anyway to download the databases (snoRNA and snRNA) instead of loading my datasets? The biomart interface seems a little bit non-intuitive

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Either download the GTF for your organism and just filter accordingly or use a biomart query like this, which won't require you to load anything.

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10.2 years ago
Chirag Nepal ★ 2.4k

Why don't you use RNACentral?

Though I have never used it myself.

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That looks like a nice one stop shop. I'd never heard of it before, thanks for pointing it out.

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I'm playing around with that database now. One thing to note about it is that the dataset you can download via ftp is a mixture of all of the species (not that it's terribly difficult to filter things with biopython). I've yet to find a convenient way to get sequences or coordinates from a single species reliably across source databases (it looks like if you select multiple databases, you only get sequences shared by them).

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