Forward simulation with SNP data

Question

[Fotis T]

Hi,

I want to simulate migration events, mutations and recombinations on real snp data, by forward simulation. I am not aware of a program that does this yet. I only know of programs that do this on random data.

So, what I want the program to do is take an input file (plink format or else) and advance it forward in time by a variety of theoretical models.

Does anybody know of a program like that?

Thank you

[BioCh'ti]

Hi, I'm also interested in simulationg SNP matrix data to test the effect of parameters such as the size of the population, the number of SNP in the context of cross-validation for Genomic Selection. Did you get further with simulating such kind of data? THX

Answer 1

[onuralp]

This is an interesting question. I have recently come across the following paper, which I think might be a good read to begin with: Forward-time simulation of realistic samples for genome-wide association studies

Please keep us posted if you find something.