Bioinformatician / computational biologist position in yeast biology & next generation sequencing.
Laboratory of Biology of Yeast Colonies (http://www.natur.cuni.cz/~zdenap), Faculty of Science, Charles University in Prague is seeking applicants for researcher position in the field of bioinformatics.
DESCRIPTION:
BIOINFORMATICIAN / COMPUTATIONAL BIOLOGIST POSITION funded by Czech-Norwegian Research Program is available at the Group of Biology of Yeast Colonies (http://www.natur.cuni.cz/~zdenap), Faculty of Science, Charles University in Prague, Vinicna 5, Prague, Czech Republic, being a part of new scientific center of excellence "Biotechnology and Biomedicine Center of the Academy of Sciences and Charles University in Vestec".
The Research Group is interested in different aspects of yeast multicellularity including questions related to topics of cell ageing, stress defense, adaptation and longevity. The research of the group currently follows two main lines: i) Development, differentiation and signaling of yeast colonies as a model of a primitive multicellular organism, with the main goal to identify the regulatory networks and signals involved in the phenotypic differentiation between the different types of chronologically aged cells developing within the colony (related to Mol Cell 46: 436-448, 2012). ii) Development, defense strategies and signaling pathways involved in formation of biofilm colonies of wild yeast (related to J Cell Biol. 194:679-87, 2011). The candidates (i.e. bioinformaticians / computational biologists, alternatively informaticians / statisticians / big data analysts) should be interested in applying their skills in both research directions; in particular, the challenges of integrating the DNA, RNA and epigenetic data obtained by next-generation DNA/RNA sequencing methodology. The project will produce a unique dataset where the cells have been characterized at the fundamental levels of molecular biology (genetics, epigenetics and expression). We envisage that such a complete dataset will facilitate unique novel insights into the biology of the yeast model system. The bioinformatician will be expected to play a central role in data processing, integration and analysis.
QUALIFICATION AND EXPERIENCE: Candidates should be comfortable at the unix / linux command line and preferably also able to write bash scripts. The candidate should also be able to program in at least one of the following languages: perl, python, java, c++, and be familiar with statistical software (preferably R). Familiarity with high through-put sequencing software is a plus: mapping tools (e.g. bwa, novoalign), expression quantification (e.g. tophat), variant calling (e.g. GATK), peak calling (e.g. MACS). Last, but not least, the candidate should be interested in applying these quantitative skills to biological data.
ELIGIBILITY, HOW TO APPLY: The applicants should have good command of English and preferentially a PhD; however, researchers who have completed University education without PhD, proficient in the tools described above, are also encouraged to apply. Please send your motivation letter, CV, list of publications (including IF and the number of citations) and reference contacts directly to the group leader Zdena Palkova (zdenap at natur.cuni.cz). The contract is available from January 1, 2015 (or by appointment) and finishes at April 2017.
