HG19 Translation discrepancy or something else?

Question

[jacobsen.jeremy]

Why is there Arginine where there should be a Tryptophan?

Translation from XPasy of rna sequence for uc001abw.1 from knownGeneTxMrna sequence:

... Q T P G Y G F L P P A Q A E Met F A W Q Q E L L R K Q N L A R ...
                                        ^

Peptide from KnownGenePep (same release):

...QTPGYGFLPPAQAEMFARQQELLRKQNLAR...
                    ^

Answer 1

[Pierre Lindenbaum]

See http://www.uniprot.org/uniprot/Q96NU1: There is a known variant at this position http://www.uniprot.org/blast/?about=Q96NU1[343]&key=Sequence%20conflict

I'm not sure how the UCSC uses this information to fill the KnownGenePep table.

[jacobsen.jeremy]

Strange. I wonder why these aren't wild type? I found a few thousand sequences like this in knownGenePep.