Is there any database that can link the germline/somatic variant to cancer target drugs?

Question

[J.F.Jiang]

Hi all,

I am doing survey to understand the relationship between variants and target drugs for cancers.

I looked into several databases, however, none can provide a summary for variants-drugs interactions for one specific cancer, e.g., lung cancer

If anyone has this source in hand, can you plz help me to figure out this issue?

Best

[Chris Miller]

Why would the type of cancer matter? If the drug targets a particular kinase, it's likely to do so systemically (in many cases, anyway). This is why drugs are being used more and more across cancer types. In any case, DGIdb is generally my first stop for drug-gene interaction info.

[Cyriac Kandoth]

You're right that in the long run, the site of the tumor may not matter. But for now, it matters to most clinicians, who care about disease management, and to not get sued for off-label use. Small-molecule precision drugs still have plenty of side-effects (though fewer than chemo) that have only been studied in clinical trials for that indication. It's going to be a while till basket trials lead to tangible evidence-based treatment guidelines based on molecular subtypes.

Answer 1

[Cyriac Kandoth]

As Chris mentioned, DGIdb lists Gene-Drug interactions. Look through their "Source Databases" to find where they grab data from. Only a few of those (like MyCancerGenome) explicitly list Variant-Drug interactions. The most decent sources are in the commercial arena, catered to pharmaceutical companies as business intelligence. Here's everything I know about: Ingenuity, Cortellis, NCCN, Citeline, OncoMD, BiomarkerBase, GVKBio.