Best way to compare rate of amino acid change between proteins?

Question

[Rubal]

Hello Everyone,

I need to compare the rate of change in amino acid sequence between a set of human proteins. The more species that can be included the better to get a sense of how quickly amino acid sequences are turning over in these proteins over a broad evolutionary timescale. Can anyone recommend any software or tools for this kind of analysis?

Thanks in advance,
Rubal