Family trio WES analysis

Question

[datanerd]

HI all,

I have a set of family trios that I wanna analyze. These are set of WES and relation is known and affected or unaffected is known. Can someone point me to the most appropriate method to analyze this? Any paper/tutorial or blog would be great or any advice if you have experience.

Thanks a lot in advance.

Mamta

Answer 1

[Kizuna]

Hi Mamta,

Try this: NGS Data from multiple families

[datanerd]

HI Kizuna,

This is helpful. thank you so much.

Would you recommend any program or tutorial to do the analysis. Like run alignment separately and the call variants together? using Unified or haplotype genotyper?

Thanks!

Mamta