Hi,
I'm a Computer Science postgraduate new to the area of bioinformatics. I have been given a dataset of a couple of SNPs with 600 subjects. I've a quantitive value, measuring disease severity.
What tools should I use to see if there is a correlation?
I'd really appreciate your suggestions.
Ummm, what do you mean when you say you have quantitative value? And, what data do you have on the SNPs exactly? The alleles involved? The frequencies they are seen in?
Thanks for getting back to me.
Let's say I have a value between 0 and 200 that represents the severity of the disease, and I have this value for each of the 600 subjects.
Then for the SNPs, I've the alleles for each subject.
Alright, is the reference allele given to you or is it just this data (Subject, Allele, Disease-Score) from which you're supposed to infer that?
Can you describe what you mean, by reference allele?
It's the allele found in the reference genome at the exact same position as your Single Nucleotide Variant.
Yes, I believe so.