Job:Junior and Senior Bioinformaticans - INVISTA - North East England

Question

[alec.foster]

Due to expansion and promotion we have several openings within the Bioinformatics group, particularly those with experience in enzyme selection/phylogenetics, docking of small molecules or flux balance analysis. Closing Date: 16th January 2015

Feel free to ask me any questions (I am a Bioinformatican)

Job 1 Senior Research Engineer/Research Scientist - Bioinformatics/Computational Biology

Ref: 29239
Location: Wilton - Teesside/UK

Responsibilities

• Application of bioinformatics tools to inform metabolic engineering strategies with the aim to construct optimized metabolic pathways comprised of recombinant and engineered enzymes for the production of bulk chemicals.
• Integration of bioinformatics resources (genomics, proteomics, literature) to aid the identification of novel genes, pathways and enzyme families for a synthetic catalytic application.
• Liaise within a multi-disciplinary team of scientists, presenting, reviewing and appraising results.

Requirements

• MSc/PhD Bioinformatics or Computational Biology.
• Applying bioinformatics and statistical tools to analyse, interpret and disseminate knowledge gained from a wide range of public/online databases, predictive tools, proprietary software and custom high-throughput biological data either independently or integratively.
• Very solid foundation in prokaryotic physiology/genetics/metabolism/enzyme catalysis.
• Ability to work in a challenging multidisciplinary environment, both independently and as part of a team.
• Experience in the visual presentation of biological data from modelling, -omics and other sources to non-bioinformatics audiences.
• Competent IT skills, including Microsoft Word, Excel, and Outlook

Interested applicants should submit a detailed CV in English along with a covering letter indicating their salary expectations to [e-mail]

Job 2 Senior Computational Biology Research Engineer

Ref: 29238
Location: Wilton - Teesside/UK

Responsibilities

• Provide sequence, structural and mechanistic insight into catalytic activity and function of enzymes to metabolic engineering team.
• Guide protein engineering strategies by interpreting catalytic variance, and using structure/function insights for the computational redesign of enzymes.
• Predict catalytic action by protein homology modelling and ligand docking.
• Integrate various resources (genomics, proteomics, literature) to aid the identification of novel enzymes for synthetic catalytic application.
• Liaise within a multi-disciplinary team of scientists, presenting, reviewing and appraising results.

Requirements

• PhD Bioinformatics, Biochemistry, Computational Chemistry, or a related field.
• Excellent analytical thinking skills and a solid foundation in general enzyme mechanisms, sequence and structural analysis.
• Expertise in applying bioinformatics tools for enzyme modeling and catalytic analysis (multiple sequence alignment, genomic context, structure and sequence homology, PyMOL/YASARA)
• Ability to work in a multidisciplinary environment, both independently and as part of a team setting.
• Molecular dynamics and protein/small molecule docking (AutoDock).
• Phylogenetics analysis
• Metabolic pathway exploration and tool development

Interested applicants should submit a detailed CV in English along with a covering letter indicating their salary expectations to [e-mail]

Job 3 Senior Research Engineer/Research Scientist - Bioinformatics/Computational Biology

Ref: 29241
Location: Wilton - Teesside/UK

Responsibilities

• Application of bioinformatics tools to inform metabolic engineering strategies with the aim to construct optimised metabolic pathways comprised of recombinant and engineered enzymes for the production of bulk chemicals.
• Bioinformatic and statistical analysis of genomic, transcriptomic, metabolomic and/or proteomic datasets.
• Utilising the -omics datasets to construct, refine and interrogate genome scale metabolic models.
• Integration of the -omics datasets to aid the understanding and engineering of the selected microbial host and also for the identification of novel genes, pathways and enzymes
• Liaise within a multi-disciplinary team of scientists, presenting, reviewing and appraising results.

Requirements

• PhD Bioinformatics or Computational Biology.
• Expertise in applying bioinformatics and statistical tools to analyse, interpret and disseminate knowledge gained from a wide range of high-throughput biological data either independently or integratively.
• Excellent analytical skills and a very solid foundation in microbial physiology.
• Ability to work in a challenging multidisciplinary environment, both independently and as part of a team.
• Hands-on experience in the analysis of metabolic networks using advanced techniques such as flux balance analysis and minimisation of metabolic adjustment to inform the design and optimisation of non-natural pathways in microorganisms.
• Experience in the visual presentation of biological data from modelling, -omics and other sources to non-bioinformatics audiences.
• Competent IT skills, including Microsoft Word, Excel, and Outlook

Interested applicants should submit a detailed CV in English along with a covering letter indicating their salary expectations to [e-mail]

Please use the job title and reference code in your application.

[alec.foster]

A bit about the company:

INVISTA seeks dynamic, high caliber scientists and engineers to join its rapidly expanding Wilton, U.K., research and development team to develop pioneering solutions to commercialise next-generation industrial biotechnology.

As part of INVISTA's commitment to innovation, it has invested in the emerging field of industrial biotechnology, operating its own biotechnology capability out of the R&D lab in Wilton. INVISTA's bio-scientists and engineers are working, alongside collaborators in academia and external technology companies, to develop new biotechnology processes and bring bio-derived products to market.

Through innovative research efforts at the leading edge of science, INVISTA has the potential to develop advantaged technologies that could significantly improve the cost and availability of several chemicals and raw materials that are used to produce its current products.

To work successfully in our team, candidates must be comfortable with a challenging fast paced environment where interdisciplinary team work is essential.

INVISTA is one of the world's largest integrated producers of chemical intermediates, polymers and fibers with a portfolio of some of the world's most recognizable brands and trademarks including LYCRA®, COOLMAX®, CORDURA®, STAINMASTER® and ANTRON®.

Answer 1

[alec.foster]

Generally we are looking for two senior roles and one other role that could be senior or junior (job advert 1).

While the roles are defined in the adverts, the skills combination will be key to candidate selection, and how these skills compliment other candidates. As its a very fast changing environment with an emphasis of rewarding contributions, these roles can evolve quickly (even junior ones).

Initially it is envisaged one of the three roles will replace my old position(Enzyme Docking, Enzyme selection, Pathway finding, Sequence analysis), another Bioinformaticians role will support strain characterisation (Metabolic modelling, RNAseq, etc), while a third role would bridge both, complimenting/learning both aspects and able to step up into either role in future.

Its an exciting role, performing cutting edge research. I would recommend applying as it gives great experience both from learning perspective and career progression.

Answer 2

[a.polo88]

Hello,

I have read about these positions, but are only for the senior? in the title I have read about junior and senior. In any case I'm interested in these positions, I would like more informations. I'm a MSc graduate bioinformatician at Univesity of Bologna in Italy. Thanks