Forum:What Are The Most Influential Bioinformatics/Computational Biology Papers Of 2014?

Question

[dago]

I really liked this discussion:

What Are The Most Influential Bioinformatics/Computational Biology Papers Of 2011?

Therefore, I think it would be nice to have it also for 2014.

This is a really good way of having an overview about what happened in the last year.

Answer 1

[Istvan Albert]

IMHO having the MinION produce useful data may turn out to be the most influential development - though there is no singular paper to point to.

https://nanoporetech.com/technology/the-minion-device-a-miniaturised-sensing-system/the-minion-device-a-miniaturised-sensing-system

[dago]

Just to add some new information to the MinION topic:

Improved data analysis for the MinION nanopore sequencer

[Istvan Albert]

thanks for posting it - I am very interested in the technology and the latest developments

[pld]

This is awesome to hear. I'm still wondering how these things deal with single stranded RNA virus genomes. The problem there is that there's usually a ton of structure in the 5'/3' UTRs. With 'normal' NGS these regions can have poor coverage but I wonder how well they would fit through a pore. It would be nice to not have to do RACE to get a full genome sequence.

Or for that matter how well can you deal with cDNA generated from viral genomes?

I really wish they'd start selling them already.

[dago]

Sorry my ignorance, are you refering tho this: https://www.biostars.org/p/86819/?

[Istvan Albert]

it is actually this https://nanoporetech.com/technology/the-minion-device-a-miniaturised-sensing-system/the-minion-device-a-miniaturised-sensing-system

turns out the word MinION is not all that searchable on the account of the Despicable Me movies

[Ram]

Google should really add case sensitive search.

Alternatively, Oxford can ship the device in a special Blue-and-Yellow Googly Eyed edition :D