Snp130-Masked Fasta Files And Alignment
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13.1 years ago
Rok ▴ 190

Hello!

I have some Chip-Seq reads that need aligning, because I want to eliminate bias towards reference alleles I wanted to try aligning with SNP-masked genome.

I have downloaded SNP-Masked sequence files from the UCSC database (http://hgdownload.cse.ucsc.edu/goldenPath/hg18/snp130Mask/), and have tried doing alignment with Bowtie. The problem is that Bowtie gives a mismatch between R (which is G or A) and G.

Is there any other software that works with SNP-masked sequences?

best wishes

bowtie dbsnp • 2.4k views
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