Question about the possibility of comparing samples based on within sample z-score

Question

[BioHazzard]

I have a novel cell line which I would like to compare to tumors of the same species by means of a kind of signature. I was wondering if the following approach could be valid, I am not a bioinformatician.

I was thinking about expressing the expression of each gene as a z-score with respect to all genes measured within the same sample, then to compare samples based on the z-scores of each gene. Then somehow testing this comparison with some kind of significance test.

Answer 1

[Deepak Tanwar]

May be this is helpful:

• http://discover.nci.nih.gov/microarrayAnalysis/Statistical.Tests.jsp
• http://archive.bio.ed.ac.uk/jdeacon/statistics/tress4.html
• http://www.nature.com/ncomms/2013/130709/ncomms3126/full/ncomms3126.html
• https://www.researchgate.net/post/What_is_the_most_suitable_statistical_analysis_to_compare_drug_response_among_several_cell_lines