What is the name of an article which is against the "The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity"

Question

[zero_hsy]

Hello:

I am find an article where its opinion is against "The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity".

Could anynone tell me the name? Thanks!

[russhh]

Give a bit more detail, as it depends which aspect of the paper you want to criticise:

• precision medicine as a whole;
• the relevance of cell line studies to in vivo drug sensitivity;
• the relevance of cell lines as a model of tumours;
• that genomic markers can be mapped to metabolism;
• the choice of drugs, cell-lines and/or markers, and potential biases therein, used by ccle;
• the prediction methods used;
• the quality of the dataset;

that the results don't match exactly with those that you have obtained in the same cells ;)

...

In fact, it might be easier for you to just write a critique yourself

[zero_hsy]

Thanks a lot.It is a paper which contains the gene expression data on the probably 600 cell lines. And its opinion is against the above article.

Answer 1

[coldrecd]

I think you are looking for this:

1: Haibe-Kains B, El-Hachem N, Birkbak NJ, Jin AC, Beck AH, Aerts HJ, Quackenbush
J. Inconsistency in large pharmacogenomic studies. Nature. 2013 Dec
19;504(7480):389-93. doi: 10.1038/nature12831. Epub 2013 Nov 27. PubMed PMID:
24284626; PubMed Central PMCID: PMC4237165.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237165/

[zero_hsy]

Thanks a lot !!