Entering edit mode
9.7 years ago
areyoujokingme
▴
70
Hello, Biostars community!
I am trying to find data, data, data. Right now, I need help finding sequencing data that comes from a person who we know to have disease X (where X represents a non-specific disease, haha).
Is there a way to gather sequence data from the multitude of sequenced genomes (as from the 1000 Genome Project, 10,000 Genome Project, etc) and separate the data into two groups - those who have disease X and those who don't (to be used as a reference), and then to compare the two groups' sequences? I have target genes of course that I will be honing in on.
I've asked a few people about this and I have not gotten any straight answers. Can anyone help me out?
What type of sequencing data are you looking for? There are a lot of different type of sequencing data available on the internet and a good place to start will be the GEO with the expression data. Unfortunately, I am not sure where can one find exome sequencing data but you can find some GWAS result in the GWAS catalog
I'm looking specifically for neuropsychiatric (most notably the affective disorders - depression, bipolar, anxiety - and the psychotic disorders - particularly, schizophrenia - sequencing data. I want to compare genomic regions of target genes between patients with a variety of neuropsychiatric disorders against reference genomes (those who do not), but I don't know where to access this.
I don't know how to use GEO or GWAS yet, but I will look into it - thanks for the direction, Sam! In general, I don't know where to look for data, so this could be really helpful. If anyone knows anything more, I would be very grateful!
If you are looking for psychiatric disorders, you should definitely check out PGC and maybe the posters from last year's WCPG
Sam this is wonderful - thank you so much! You've just opened many doors for me!
TCGA holds data from cancer patients, if that helps :)
https://tcga-data.nci.nih.gov/tcga/