How to combine bisulfite sequencing data with Medip seq and/or MRE-seq

Question

[Saad Khan]

I was wondering if anybody has done integration of data from two different sequencing methods for DNA methylation like bisulfite-seq and Medipseq.I would really appreciate if someone could suggest methods for the same. Thanks

Answer 1

[mark.ziemann]

Do you have control/treatment data for both?

My suggestion would be to focus on promoter regions +/- 1kbp around TSS and quantify the methylation in each case, %methylation for BS-seq and counts per million for MeDIP-seq, then you can analyse differences with statistical test, merge datasets on gene accession number and perform correlation analysis.