Automate protein family analysis

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9.5 years ago

biotech ▴ 570

I need to perform various analysis focused on a particular protein family, trying to reveal some of its evolutionary chracteristics. I would like to automate as much as possible this task. The sequences are now inside genomic data, so maybe I need to start by extracting them from the genomes?

I will work with 200 bacterial genomes. Also, since there are repetitive sequences inside this target proteins, some of them will have a gap. Hope this is not a big caveat.

Thanks

protein-family • 1.8k views

ADD COMMENT • link updated 22 months ago by Ram 44k • written 9.5 years ago by biotech ▴ 570

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what does it mean "various analysis"?

ADD REPLY • link 9.5 years ago by dago ★ 2.8k

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Enough for a paper.

ADD REPLY • link 9.5 years ago by biotech ▴ 570

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Domain annotations, dS/dN ratios, homology, phylogenies, rearrangements, among others.

ADD REPLY • link 9.5 years ago by biotech ▴ 570

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I though about creating some kind of database of target protein sequences and then running programs in a semi-automated fashion.

ADD REPLY • link 9.5 years ago by biotech ▴ 570

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