What is the difference between fine-mapping and targeted sequencing?

Question

[genetic]

As far as I understand, targeted sequencing is for examine entire region of genes, and fine-mapping is examine certain GWAS loci. Can I say that fine-mapping is kind of targeted sequencing?

Thank you,

Answer 1

[Ying W]

Ehh, not really. My understanding is as follows:

Fine mapping is to go from tag SNPs in GWAS to identifying the causal SNPs

Targeted sequencing is a generic term to use some kind of capture technology to enrich for certain part of the genome before doing sequencing.

Its more accurate to say that you can use targeted sequencing for fine mapping.

Answer 2

[genetic]

Thank you for the clarification!

[Ying W]

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