Is There Clear Description Of Each Human Dbsnp Build Somewhere?

Question

[Noel]

Respected colleagues,

When dealing with filtering parameters for calling variants in my NGS data I am struggling with the choice of using the right dbSNP for hg19. The incorporation of rare variants with pathogenic potential in latest builds makes me nervous about filtering all SNP's out. Apparently the last "clean build" is db129 but that one is hg18 of course. A specific question relates to the difference between db134 and db132. It seems that db134 only has half the number of variants present in db132. Could this be viewed as a "clean build"?

Warm regards,

Noel

Answer 1

[Pierre Lindenbaum]

a summary for each release of dbSNP is available here ("See summary for past builds:"):

<http://www.ncbi.nlm.nih.gov/projects/SNP/snp_summary.cgi>