I am using the STRING protein interaction database. I have problem of how the combined score of an interaction is calculated. In this reference http://nar.oxfordjournals.org/content/33/suppl_1/D433.long, it stated the combined score S=1-(1-S_1)*...*(1-S_8)
, where S_i
is the score from the ith evidence. However, this result http://string-db.org/newstring_userdata/tabdelimited.P5Gb87rP_Ayk.txt shows the discrepancy, that two interactions have identical individual scores but different combined scores (though only slightly different)
HRAS RASA1 1849235 1846381 ENSP00000309845 ENSP00000274376 0.000 0.000 0.000 0.000 0.000 0.000 0.900 0.000 0.899
DOK2 IL2RB 1846493 1842567 ENSP00000276420 ENSP00000216223 0.000 0.000 0.000 0.000 0.000 0.000 0.900 0.000 0.900
Another two examples showed great discrepancy between the observed combined score and that of the computed by the mentioned formula http://string-db.org/newstring_userdata/tabdelimited.ThlUvDQgUN9n.txt
IKZF2 IKZF1 1860848 1851367 ENSP00000410447 ENSP00000331614 0.000 0.000 0.000 0.950 0.000 0.576 0.000 0.574 0.587
ZPBP2 ZPBP 1851843 1842216 ENSP00000335384 ENSP00000046087 0.000 0.000 0.000 0.851 0.000 0.000 0.360 0.890 0.444
Is this a bug or there is a different formula to calculate combined score from individual scores?