Conservation of protein interaction site

Question

[Pappu]

I am trying to find out the relative conservation of residues of a protein that interacts to another protein over other surface residues. For example, 10 residues of protein A interacts with protein B. I want to quantify the conservation of those residues over other surface residues. I am wondering if there is any statistical or quantitative method for doing it.

[Pallab Bhowmick]

Have a look in this article and I think it will help you to find your answer http://www.pnas.org/content/102/43/15447.abstract