how to normalize chromosome arms?

Question

[mangfu100]

Hi all.

I have some questions regarding the distribution of copy number variations.

While reading some papers, I found that they often grouped the CNVs according to its size.

As shown in figure a, this paper used a normalized chromosome arms to separate focal and arm-level SCNVs.

However, I don't know how to normalize chromosome arms. Does this mean the Z-score of each segment's length? I don't think so.

Can you help me to measure the normalize CNVs according to chromosome arms in detail?

[Shixiang]

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