How to handle the problem of one probe set ID mapping to several genes in HG-U133 plus 2?

Question

[mgab]

Hi all. I am using HG-U133 PLUS 2 platform. I am having one problem of one probe set ID mapping to several genes? How can one resolve this problem? is there a bioconductor software that deals with this problem? Thank you.

Answer 1

[Chris Evelo]

Yes there is. The common way to solve this is to use alternative probeset annotations. These are available as custom .cdf files from the brain array website. These custom cdf files solve a number of other problems with bad probes too.

One easy way to use these is via our arrayanalysis.org service that allows you to do quality control, normalisation, statistical modelling and pathway analysis using these custom ,cdf files if you select these.

[mgab]

Thanks Chris. I will use this software. Excellent.