Shrinking fold change and dispersion for RNA-seq data ( DESeq2)
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9.1 years ago
schmilblik ▴ 20

Hello biostars,

I'm new to RNA-seq and I'm trying to introduce myself to DESeq2.

My question is: Why do we need to shrink the fold change and dispersion for RNA-seq data?

Thanks in advance

RNA-Seq DESeq2 • 4.7k views
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9.1 years ago
Michael Love ★ 2.6k

I'd recommend trying to read the DESeq2 paper from 2014 (we wrote it with non-statisticians in mind), but you might also try this post on another thread:

A: Can someone please explain in simple terms how DESeq2 works?

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