SNP Data from dbSNP
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9.1 years ago

Hello,

I am currently doing a study on the effect of a SNP on a certain population. I was looking at the dbSNP website, and I noticed that the same subjects had different genotypes in different databases. For instance, one person may have a CC genotype while having a GG genotype in another database. Which genotype should I use and why?

Thank you for answering my question.

SNP • 1.7k views
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it's a strand problem. Welcome into the wonderful world of bioinformatics.

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You have to find the reference allele and standarize your strands, to say be only the "+" strand. That way you can easily flip any non matching SNPs.

Read on plink

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