What Are The Costs Of A High Throughput Screening With A Chemical Compound Library?

Question

[Edrin]

Hi,

imagine you are looking for inhibitors for a certain pathway and you have a test, i.e., wild type vs. mutant cell survival, to find these inhibitors,

what are the costs of a high throughput screening with a chemical compound library?

How can I find a HTS facility that also provides a chemical compound library (>10.000) and is willing to perform the screening in collaboration?

Is there a way to perform such a (very promising) screen for free and the results are "shared"?

[Michael]

even if some people like the question, it is off topic unfortunately. Yes it is about high-throughput, and yes you will need some statistics and maybe bioinformatics to design the experiment and interpret the result. But you are asking about the price, I think you should ask somewhere else. I don't know where though, so I suggest to keep the question open until we know a better place and then close it.

[Larry_Parnell]

I can agree to that. If the question were directed toward mining data from PubChem or ChemBank, for example, then it is appropriate for this forum.

Answer 1

[Rajarshi Guha]

Assuming you're willing to pay, you could look at CRO's (e.g., http://www.labelindependent.com/pages/drug_discovery_screening.html). Alternatively, you could try getting in touch with a MLSCN member, though this would likely involve the writing of a joint grant application

Answer 2

[Andrew Su]

Three suggestions from me:

• GNF (my former employer) does do academic collaborations for high-throughput screening of either compound libraries or functional genomics libraries. Can't find mention of it on the website, but the collaborations are generally structured as you described.

• AssayDepot also seems ideally suited for this type of one-off project, but I don't know how/if "free" could be worked out.

• MLPCN, seconding Rajarshi's suggestion.

Answer 3

[Larry_Parnell]

For free? Certainly. Take a look at PubChem. Many screens are available. You can also try ChemBank from the Broad Institute:

ChemBank is a public, web-based informatics environment created by the Broad Institute's Chemical Biology Program and funded in large part by the National Cancer Institute's Initiative for Chemical Genetics (ICG). This knowledge environment includes freely available data derived from small molecules and small-molecule screens, and resources for studying the data so that biological and medical insights can be gained.

Answer 4

[Flow]

You can try to get funding for this: http://www.screeningport.com/