How to perform correlation between unmatched miRNA and mRNA data?

Question

[Masood]

How can we perform correlation analysis between unmatched microRNA and mRNA expression data?

Thanks in advance.

[5utr]

I think you should explain what you mean with 'unmatched', you can only calculate correlation on matching samples.

[Masood]

Thanks Gian for your reply.

You are right that we can only calculate correlation on matching data but in my case data is like following:

miRNA = 4 NormalSamples - 6 TumorSamples

mRNA_Gene = 4 NormalSamples - 5 TumorSamples

I want to calculate the inverse effect of miRNA on mRNA gene.

I have also asked similar sort of question with more detail but didn't got any reply yet.

Correlation of unmatched microRNA and mRNA expression data.

Thanks :)

[5utr]

First you need to exclude the samples that are not in both datasets and then you can calculate the correlation on the overlapping subset. Since you are using R you can merge the two matrix and then calculate Spearman correlation between all miRNAs and mRNA