How to calculate 4DTv distance (D4DTv) that stands for fourfold synonymous third-codon transversion ?

Question

[Michel Edwar]

Hi guys,

I have a multiple sequence alignment and I need to calculate 4DTv distance (D4DTv) that stands for fourfold synonymous third-codon transversion. I wonder if there is a program which can calculate it or a function in R?

Thanks

[Matteo Schiavinato]

Do you have an answer to your question? I'm doing it now and it is not easy to find people who did it already.