SKAT-O for recessive variants only
0
0
Entering edit mode
8.9 years ago
wanabi ▴ 60

Hello,

I want to see if some genes of interest have an increased burden of alternative homozygous variants in cases versus controls. Is there an easy way to implement this in SKAT?

Something I am considering doing is creating a dummy VCF file in which reference homozygous and heterozygous variants are set to 0/0 and alternative homozygous are kept unchanged (0/1). I will then run SKAT over this file. Is this a sensible approach?

Thanks a lot

SKAT SKAT-O skat skat-o • 2.5k views
ADD COMMENT

Login before adding your answer.

Traffic: 1614 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6