Is there a database which gives meta-level information of mutation(both nuclueotide and AA change) for specific pathways?

Question

[ivivek_ngs]

I would like to know if there is a database of pathways where a single pathway can give meta level information of nt change and AA changes. Unlike COSMIC it provides all informations based on a gene and help us knowing what are the different level of mutation have been recorded for that gene and we can see the spectrum. But is there any pathway database which can give me a list of mutations that are causal for that pathway, and am looking for a list that records both the base change and the AA change.

Let's say we look for some specific pathway: Receptor tyrosine kinase pathway and I want to retrieve information of list of mutations (both at nt level and AA change level), types of cancer, mutational spectrum that attributes to this pathway. This query might be very trivial but I cannot find any such open database. Is there such pathway database that can list out this kind of information.

Thanks

Answer 1

[Chris Miller]

I'm not aware of such a database, but it could be cobbled together using something like DOCM and the pathway database of your choice.

Answer 2

[ivivek_ngs]

I guess it would be the same if I am using COSMIC, since am interested in cancer somatic mutations, but is DOCM having more curation than COSMIC? Chris Miller

[Chris Miller]

Cosmic contains everything, including a huge number of passenger mutations. If your question is "has this muration ever been seen in a tumor", start with Cosmic. If you're looking for a list of verified driver mutations, DOCM is a decent place to start. The major caveat is that DOCM is still fairly new and is not as comprehensive as it could be. (Its better for some cancers, like AML, than others)

[ivivek_ngs]

Thanks a lot , pretty much sums up.