--maf_exac flag not found in VEP77

Question

[arronslacey]

Hi,

I would like to get the exac allele frequencies by using the --maf_exac flag in VEP.

My install of VEP included building a cache from homo_sapiens_vep_77_GRCh38.tar.gz

After letting the installer script build the cache, I then tried:

perl variant_effect_predictor.pl -i myinput.txt -o myoutput.vcf --cache --maf_exac --polyphen p --sift p

to which I got:

Unknown option: maf_exac
ERROR: Failed to parse command-line flags

It seems that although I am using --maf_exac in conjunction with a cache as recommended in the documentation, VEP is not recognizing --maf_exac as a valid input.

Is there a problem with my command?

Thanks

Answer 1

[Emily]

The --maf_exac command was only introduced into the VEP in release 83. Please update to the latest version to use this command.

[arronslacey]

thank you emily this worked. It's been a while since I used VEP, but re-cloning the github I didn't realise there were plugins - good day for me!