Database in which Compounds are classified according to diseases

Question

[Janeeta Raja]

Is there any database available in which compounds are classified according to diseases and is downloadable? For example all the compounds which are involved in Alzheimer disease. Regards.

[Benn]

Did you check NCBI? Like PubChem or other chem. databases in NCBI?

There is a ftp download tab as well.

[Janeeta Raja]

Yeah I checked but compounds in them are not categorized...

[michael.ante]

I think you can use OMIM to get the phenotype number and use this ID as the Cross-reference "MIM" identifier in Uniprot: example Alzheimer disease query You also may go over the linked genes to the gene-products.

[Janeeta Raja]

Thanks.I want compounds not genes or proteins.

Answer 1

[GenoMax]

Take a look at PharmGKB. An illustrative example.

[Janeeta Raja]

Thanks but these are only drugs I want all the compounds which are in pathway of diseases.

[GenoMax]

Can you clarify what you mean by?

compounds which are in pathway of diseases

[Janeeta Raja]

Compounds which dock with proteins and results in onset or inhibition of diseases.

[GenoMax]

Hmm that is a pretty tall order. Some of the drugs will fall into the latter class but I am not sure if a lot is known about the first part.

[Janeeta Raja]

Thats the main problem...Okay thanks for your help..

Answer 2

[bulldogshepherd]

Try KEGG. Each pathway or disease contains compounds (entry ID Cxxxxx). http://www.genome.jp/kegg/pathway.html

[Benn]

Be aware of the fact that KEGG is paid subscription nowadays for ftp downloads.

[Janeeta Raja]

Yup these are not freely available.