Representative member of a paralogous group of proteins

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8.7 years ago

RT!37 ▴ 20

From a group of paralogs, how to select representative member in order to prevent overrepresentation in my dataset.

sequence • 1.2k views

ADD COMMENT • link 8.7 years ago by RT!37 ▴ 20

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What do you mean by "overrepresentation"? If there is a chance that they have functionally evolved then you will need to consider them all unless you know a duplication is recent and has not had time to evolve.

ADD REPLY • link 8.7 years ago by GenoMax 147k

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Thanks

Hi, From over-representation I mean , being a slight difference in sequence but similar function proteins occurrence multiple times. For my study, i want to exclude such proteins. The duplication event is recent or early can be known only by looking divergence of function (neofunctionalization). But since large number of proteins are there in dataset, manually selecting based on function is not an option. Is there any resource or threshold value to decide the representative member from a group of paralogs proteins.

ADD REPLY • link 8.7 years ago by RT!37 ▴ 20

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