T Cell CDR3 sequence database

Question

[bioinformatics.cancer]

Hi, I was wondering if anyone is aware of a database of TCR CDR3 AA sequence and matching (binding) Antigen epitope AA sequence, in general of in the field of immuno-oncology in particular. Thanks, - Pankaj

Answer 1

[mikhail.shugay]

Hello Pankaj,

I've recently started an initiative that fits your question, see https://github.com/antigenomics/vdjdb-db, releases section. There are currently few cancer epitopes listed there and we are still in progress of making the database specification, however there is a lot of information on CMV/EBV epitopes. I'll also greatly appreciate contributions in form of pull requests, pending papers are listed in the issues section.

[bioinformatics.cancer]

Thanks Mike, I will certainly do the needful. Hope to participate in the progress of this project, I think it could be a great contribution to the field. - Pankaj