calculating the conservation between TADs with statistical significance

Question

[ancient_learner]

Hi All,

The http://chromosome.sdsc.edu/mouse/hi-c/download.html link gives the TAD regions identified using domaincaller algorithm. If i want to see the conservation of those TADs between the cell types as well as species based on genomic positions how can i do that? I know the jaccard index from bedtools but I feel it is inappropriate. can correct me if i am wrong.