Cancer metastasis and its primary site of origin

Question

[preciouspops]

How could one use sequencing data ( in particular - whole genome sequencing data) to determine tissue of origin of cancer’?

Can any one share their ideas on the above question.

I could find out few papers such as Tumour tracer method and few regression algorithms.

At a higher level can pathway analysis can be done to estimate primary site of any cancer cell??

Answer 1

[Chris Miller]

You'd probably have better luck with using gene expression data. Nothing about somatic mutations is inherently tied to particular tissues, unless it's something like a metastasized melanoma (where the UV light mutation signature might suggest something about the origin)

[preciouspops]

Thank you chris for swift response . Is it possible computationally to determine origin of cancer cells using gene expression data??

If so can you please summarise

[Chris Miller]

You'll have to search through the literature for methodology. This seems to turn up lots of papers: https://www.google.com/search?q=gene+expression+tumor+site+of+origin&oq=gene+expression+tumor+site+of+origin&aqs=chrome..69i57j0.6648j0j7&sourceid=chrome&ie=UTF-8

[preciouspops]

Thanks a ton Chris :)