mutation signature in cancer

Question

[2nelly]

Hi all,

Does anybody can suggest me a tool to detect mutation signature in cancer? Preferably not an R package

Thank you in advance!

[Irsan]

I don't think you will get any useful responses unless you explain a little bit more about your research rationale, study design, hypothesis etc.

[2nelly]

sorry, but I think I was pretty clear! It doesn' t have to describe the rationale and my whole study to get an answer on that!

I just need a tool to detect snv signature in cancers samples, like in that image below

http://cancer.sanger.ac.uk/signatures/Signature-1.png

[Irsan]

What people mean with a mutation signature varies a lot. I see that after you have explained that you mean the signatures defined by cosmic you got a useful answer. But still it is unclear for example whether you managed to process reads to variants, which is required input for the suggested programs.

Answer 1

[poisonAlien]

EMu (C++)

Mutational Signature Framework (Matlab)

Answer 2

[maduh17]

Awesome, I was just going to ask a similar question! Rather not write the code from the Methods by the original paper by Alexandrov!