Hi guys, I'm wondering how many (%) genes in the genome carry mutations that are not cancer-related? Specifically...all we know that there are mutated genes like TP53 or MYC or others that are mutated in cancer and we know that the occurrence of the mutation is causally involved in the disease. But a large fraction of genes in the genome carry mutations not cancer-related or better, whose involvement in cancer is still unknown. Do you know how many genes (in %) fall into this second "category"?
Best regards
B
This (doi:10.1038/nature17676) paper published today may have an answer for your question (for breast cancer atleast).