How to classify cancer genes as oncogene & tumor suppressor gene?

Question

[Pranavathiyani G]

I have a list of genes, which are possibly cancer causing genes, how can i classify them as oncogene or tumor suppressor gene? Based on what, genes can be classified as oncogene and tumor suppressor gene?

Answer 1

[Obi Griffith]

A very similar question was asked previously: Database Of Tumor Suppressors And/Or Oncogenes

This paper also addressed the topic and provides a method based on mutation data: http://www.ncbi.nlm.nih.gov/pubmed/26209800

[Giovanni M Dall'Olio]

I would add the 20/20 rule introduced by Vogelstein in 2013, which I think was the first formal definition of a rule to determine tumor suppressors and oncogenes.