Question

Why are SNPs with small effect sizes a problem for GWAS?

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8.5 years ago

joshf ▴ 50

Why does increasing a sample size increase the power for detecting SNPs with small effect sizes?

GWAS • 2.1k views

ADD COMMENT • link updated 8.5 years ago by H.Hasani ▴ 990 • written 8.5 years ago by joshf ▴ 50

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Why do you think? Is this a homework question?

ADD REPLY • link 8.5 years ago by Devon Ryan 104k

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No, it's not, but I'm learning about the GWAS (in this case its disadvantages) for an internship

ADD REPLY • link 8.5 years ago by joshf ▴ 50

score 1 · Answer 1 · 2016-06-21

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8.5 years ago

Devon Ryan 104k

Increasing sample size allows you to more confidently measure variability. That leads to an increased ability to discern smaller differences.

ADD COMMENT • link 8.5 years ago by Devon Ryan 104k

score 0 · Answer 2 · 2016-06-21

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8.5 years ago

H.Hasani ▴ 990

You may think of it backwards, e.g. if you have a bowl with 100 colorful balls, and you are interested in the black ones, which their true proportion in this bowl are 5%. Then your average chance of detecting it in 10 balls will be ~ 0.01, i.e. almost none.

ADD COMMENT • link 8.5 years ago by H.Hasani ▴ 990