Forum:Application of Genetic Algorithms in bioinformatics

Question

[liujingjing7899]

How can we apply genetic algorithms to the field of bioinformatics? What kind of problems can genetic algorithms attempt to solve?

[Benn]

If this is the title of your new book, I am looking forward to read it ;-P

[Emily]

I think it's more likely that it's an essay question for University.

[Damian Kao]

This is way too vague of a question. Perhaps this should be more of a discussion forum post. I'll change it to a forum post. I've also edited the question to be a bit more specific.

[Medhat]

can you be more specific about the question Or,

this is the answer

the use of genetic algorithms in bioinformatics

[pld]

The lab I spent most of my undergrad years in does work with GAs: http://erilllab.umbc.edu/research/projects/

[WouterDeCoster]

It's more the other way around, applying bioinformatics algorithms to genetic problems, e.g. phasing or assembly.

[Ram]

Given our use of heuristics and optimal solutions, I'd say the principal statement also holds true - we do use GAs.

Answer 1

[samuelmiver]

I assume you are looking for examples of application:

An adaptive genetic algorithm for selection of blood-based biomarkers for prediction of Alzheimer's disease progression

Genetic algorithms applied to multi-class prediction for the analysis of gene expression data

GenClust: A genetic algorithm for clustering gene expression data

And to satisfy the character "R" in your tags:

GALGO: an R package for multivariate variable selection using genetic algorithms.

[Collin]

An additional example for analyzing cancer sequencing data is: SubClonal Hierarchy Inference from Somatic Mutations: Automatic Reconstruction of Cancer Evolutionary Trees from Multi-region Next Generation Sequencing

[liujingjing7899]

Thank you for your guidance, I learned a lot。

Answer 2

[liujingjing7899]

Thank you for your guidance, I learned a lot。