Mechanisms of Hypermethylation of CGI in Cancer

Question

[Shicheng Guo]

Hi All,

Any literature to recommend to answer the question: the mechanism that result in hypermethylation of repressed CGI promoters? Meanwhile, What caused hypo-methylation in non-CGI regions?

Thanks.

[GenoMax]

While someone provides an authoritative answer you can take a look at:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662888/

[zwdzwd]

IMHO, CGI hypermethylation on tumor repressors is largely due to selective adaptation. Can have multiple possible mechanisms including a malfunctioning TET or DNA damage-induced methylation.

nonCGI hypomethylation is mostly due to cell division-induced loss of DNA methylation in cancer.

see for example, http://www.ncbi.nlm.nih.gov/pubmed/23540689