Topology of residues in proteins

Question

[agonic]

I have a large dataset of Uniprot-Accessions for proteins. If I look at a specific position in these protein's sequences, I want to know if this residue is buried or exposed (i.e. on the surface). These positions represent dbSNP entries that cause missense mutations, if that is of any help. The goal is to combine that with Pfam domain data to predict whether a residue is part of a protein-protein interaction interface.

I know that I could download the PDB files, run DSSP and calculate the relative surface area, but before implementing that I wanted to make sure there isn't any database with entries like this that I have missed.

[microfuge]

There are several tools for predicting solvent accessibility using primary sequence. Example http://link.springer.com/chapter/10.1007%2F978-3-642-23208-4_13

[natasha.sernova]

There are other tools to compare, See these posts:

how find relative solvent accesibility

Any tools for predicting protein solvent exposure/accessibility?

This article may help too:

Predicting Protein Structural Features With Artificial Neural Networks

https://www.aaai.org/Papers/Hunter/04-Holbrook.pdf