Entering edit mode
8.3 years ago
srivastavaisha.06
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20
Hello everyone,
How do we know that a particular protein molecule is targetable by any drug molecule or not? What are the properties that make a protein molecule druggable?
Thanks Simi
This is not exactly a bioinformatics question, I guess. You might be better of posting this at http://biology.stackexchange.com/ (This can get closed because not bioinformatics.)
Although I have no background in pharmacology, a protein should be accessible (preferentially cell surface molecule), your drug-protein interaction should be specific (avoiding side-effects by interaction of your drug with other proteins) and your protein should not have too many functions or vital in too many tissues (because, again, side-effects).
But obviously this would depend on the disease and protein in question. You would probably tolerate a few side effects in cancer therapy, but absolutely not when treating a common cold.
sure i ll post my que in stackexchange.Thanks for ur kind reply.