Thermal stability of protein

Question

[kolyadenkoilya94]

Hi everybody. Are interested in this question: what software can be used to study protein thermodynamics? Which is better and which is worse. Are there any program with the ability to make changes directly in the structure itself, or for that use third-party software?

[kolyadenkoilya94]

are interested in the program name, as at this time the level of knowledge of programming languages does not allow to work with code

Answer 1

[natasha.sernova]

This is mostly theory:

A fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function

https://depts.washington.edu/sfields/pdf/araya_pnas.pdf

See the list of different tools in chapter 14 here:

Advances in Protein Thermodynamics, 14.

Computational Approach-Computer Simulation of Proteins for Thermodynamics and Structure Prediction

http://www.esciencecentral.org/ebooks/advances-in-protein-chemistry/advances-in-protein-thermodynamics.php

See this article for another approach:

Robust and convenient analysis of protein thermal and chemical stability

http://sci-hub.cc/10.1002/pro.2809

These sites may be useful as well:

COREX/BEST server: a web browser-based program that calculates regional stability variations within protein structures

http://bioinformatics.oxfordjournals.org/content/21/15/3318.full

Web-server for the estimation of protein stability changes upon mutation and sequence optimality

Something unexpected...

http://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-12-151

[kolyadenkoilya94]

Thanks for your comment. But Core/Best is not working now. How do you think: Can I use Desmond or Discovery studio software for my goals?