Clinical significance ClinVar

Question

[onemoreuser]

I searched in ClinVar documentation but I didn't find anything that explains what means a clinical significance "association". The variant is associated with a condition, right? But does it say if it's pathogenic or benign?

Answer 1

[Denise CS]

"Association" is used 'For variants identified in a GWAS study and further interpreted for their clinical significance.' according to the ClinVar docs. I believe it's yet unknown whether the variant is pathogenic or not. If it was known, the clinical significance would have been "pathogenic" or "benign", I reckon.