Predict if the mutation is activating or deactivating

Question

[Chirag Nepal]

Hi there,

Does anyone know a tool that can predict whether a given SNV/INDEL has activating or deactivating effect. There are many tools that can predict whether a mutation is deleterious or not. But i did not find information regarding if that mutation is activating or deactivating.

thanks !!

[fusion.slope]

for activating mutation you meant "gain of function" mutations?

[John]

I was thinking X-Men.

[Chirag Nepal]

Yes, i meant gain of function.

Answer 1

[Amitm]

hi, In case your interest is in human samples, then have a look at OncoKB and MutationAssesor. Not everything under the sun is 'annotated' though, in fact for OncoKB it is a select few. Both of the above are used in the cBioPortal data