What is differences and similarites between NCI60, CCLE, CMAP?

Question

[m.koohi.m]

Hi,

These three database seems apply chemical compounds on different cell lines. But I could not understand what is differences and similarities between these databases. Could you possibly help me to understand these better.

Thank youm

Answer 1

[Ying W]

• NCI60 contains data (growth inhibition / cell death) of 60 different cancer cell lines when exposed to many different types of compounds
• CCLE contains data (RNA expression / DNA copy number changes / mutations) of many cancer cell lines (no data on compounds)
• cmap contains data (RNA expression changes) on cell lines exposed to compounds. It is also a tool to analyze these interactions.

As a disclaimer, I just skimmed the cmap abstracts and didn't login in