Deciding for the threshold for scores?

Question

[aaaburak20]

I have about 270 genes that are related with alzheimer's disease and these genes are scored depending upon their relavancy with the disease. I want to decrease the number of genes that I have to see most relevant ones. First I need to decide for a threshold. How can I decide for a threshold? Is there any implementation that I can use to classify those genes depending upon their scores? Also is there any criteria that I can use to classify genes and get the ones which are most important?

Thanks

[Devon Ryan]

Have you tried just plotting the score distribution? You might get lucky and they already fall into two groups accordingly.

[Ido Tamir]

Hehe! how often did you hope for this and it turned out like this?

[Devon Ryan]

There's often at least somewhat of an indication.

[lakhujanivijay]

How did you calculated the relevancy score at the first place?