Can anyone help shed light on the interpretation/meaning of untransmitted alleles in the TdT test ?
For example, in a cohort study, untransmitted SNP1 and transmitted SNP2 are significantly associated with the disease group.
As "transmission" of SNP2 is significantly associated with the disease group, it can be interpreted as SNP2 is a disease susceptibility locus and may be causally associated with the disease or genes/SNPs around SNP2 (due to linkage disequilibrium) are causally associated with the disease.
However, what would be the interpretation of SNP1? As "transmission" of SNP1 is NOT associated with the disease (or rather un-transmission IS associated), is SNP1 a protective locus or the presence of SNP1 is "statistically speaking" NOT associated with the disease ?
Any help on the interpretation will be appreciated !
